4.2.3.2.1.2 Normal shrinkage

## [1] "Intercept"                                      
## [2] "tissue_region_Hippocampus_vs_Frontal.cortex"    
## [3] "tissue_region_Pituitary.gland_vs_Frontal.cortex"
## [4] "group_Fluoxetine_vs_Control"                    
## [5] "group_Acupuncture_vs_Control"                   
## [6] "group_model.of.depression_vs_Control"

Figure 4.49: Volcano plot. 13 significant genes according to Pvalue < 0.05 and |log2FoldChange| > 0.5 are highlighted in red and available in this table.

• Enrichr results for all deregulated genes are available here
• Enrichr results for upregulated genes are available here
• Enrichr results for downregulated genes are available here
• g:Profiler results for all deregulated genes are available here
• g:Profiler results for all upregulated genes are available here
• g:Profiler results for all downregulated genes are available here
• g:Profiler results for comparison of the three queries above are available here

This heatmap was used to check fold change sign is correct for this design: We can see ASAP1 is overexpressed with Fluoxetine, which can be consistently seen on integration dotplots for the design GSE84185-FluoxetineVsControlForNoStressedInDentateGyrus.